Malnutrition, Inflammation And Arteriosclerosis Syndrome Risk Patients

Malnutrition, inflammation and arteriosclerosis syndrome Risk patients

Today it is known that patients with chronic renal failure treated with dialysis, show characteristic clinical signs of chronic inflammatory processes. Keep in mind that in this syndrome the resistance to erythropoietin, promotes atherosclerotic disease, reducing quality of life and increasing hospitalization and mortality. For this reason in the following test, the knowledge of malnutrition, inflammation and atherosclerosis in patients with chronic renal failure will be deepened, as well as their classification.

First, it is worth mentioning that the presence of protein caloric malnutrition is observed in 20-50% of patients with hemodialysis, related to the risk factors of cardiovascular disease and with the increase in levels of inflammatory markers. All metabolism disorder is related to protein hypercatabolism, metabolic and nutritional effects. In chronic inflammation many are presented and in close collaboration they generate a complex malnutrition syndrome.

On the other hand, it has been possible to relate arteriosclerosis and uremic malnutrition with this inflammatory process, configuring the term malnutrition, inflammation, arteriosclerosis syndrome to specifically reference uremia and dialysis patients.

Second, between the malnutrition syndromes, two forms of presentation have been defined: Type 1: characterized by slight hypoalbuminemia, without inflammation, normal C-reactive protein, caloric-protein intake decreased by uremia, energy expenditure at normal rest and that ofCharacteristic mode responds to nutritional supplementation;While type 2: is characterized by the presence of complex malnutrition and inflammation syndrome, with a marked decrease in serum albumin, increased PCR, normal caloric-protein intake or decreased by inflammation, high rest expense, and notIt usually responds to nutritional supplements.

Third, to date there is no single treatment to relieve the multiple negative consequences of uremic emaciation or chronic inflammation. Therefore, it is appropriate to address problems through two major approaches: one the administration of nutritional supplements and two anti -inflammatory interventions. As for the nutritional, proteins and calories of patients with advanced chronic kidney disease should meet the greatest needs after initiating dialysis.

Finally we can say that the possible causes of this syndrome include different comorbidities, oxidative stress, loss of nutrients that occurs through dialysis, hyporexia, uremic toxins, hyperphosphatemia, elevation of inflammatory cytokines, volume overload, among others. Malnutrition, inflammation and atherosclerosis syndrome is responsible for the high mortality that patients with chronic terminal renal failure present.

Bibliography

1. Sánchez M, Maldonado or. "Malnutrition, inflammation and atherosclerosis syndrome in the chronic renal insufficiency". [Internet]. Barranquilla, Colombia;2018. [Consulted September 5, 2019]. Available at: https: // www.Scientedirect.com/science/article/pii/s0122726218300636alumno: Gino Gamarra Espinoza