Research Proposal

Research Proposal
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Institutional Affiliation

Research Proposal
Introduction
Stress is one of the lifestyle conditions that affect a significant number of the modern population. The study by FitzGerald, Kehoe, and Sinha (2009) indicates that when patients have an inadequate response mechanism to stress they are likely to suffer from the irritable bowel syndrome. The study is significant in that it provides an amicable mechanism to resolve the challenges that people who suffer from irritable bowel syndrome encounter. The need for the research is justified as the primary aim of treatment is to ensure that individuals lead healthier lives later. Thus, when stress hampers those living with irritable bowel syndromes from leading healthy lives, it becomes a significant challenge. The proposed work is innovative in several aspects. It presents a framework upon which further health deterioration can be eliminated. By providing amicable methods for investigating the types of responses that the neuroendocrine systems produce in times of stress seeks to help lower the impacts of adverse health conditions on the wellbeing of a patient.
The literature review of the research is cogent, succinct and reliable. It lays a stable foundation for future studies through the identification of its shortcomings. It ensures that clinicians can derive a platform upon which clinicians can also recommend future solutions for the sick thus guarantee their wellbeing. The study design incorporates both experimental and qualitative approaches to ensure that relevant data is garnered for effective responses on how to deal with individuals suffering from irritable bowel syndrome in times of acute physical stress.

Literature Review
Other studies have also evaluated the impacts of stress in the pathophysiology of the functions of the human body. The research by Kennedy, Cryan, Quigley, Dinan, & Clarke, (2014)) suggests that stress is also a critical factor that affects the gastrointestinal (GI) disorder. The study also emphasized that acute experimental psychosocial stress is a significant trigger for individuals who suffer from irritable bowel syndrome. Alternatively, Chang et al. (2009), explains that having poor responsiveness contributes to the pathophysiology of irritable bowel syndrome. Outcomes are similar to those of the study by Chang (2011) who emphasizes that stress is a negative element for individuals who experience irritable bowel syndrome. Apparently, prolonged stress levels affect the adrenal hormones, which are known to elevate the cortisol effect of persons suffering from stress (Sugaya, Izawa, Saito, Shirotsuki, Nomura & Shimada, 2015). Kano et al. (2017), also admit that stress is a known trigger of irritable bowel syndrome. Similar to the findings by FitzGerald, Kehoe, and Sinha (2009), the study also affirms that the responses of the hypothalamic pituitary adrenal (HPA) axis are dependent on the autonomic responses of the corticotropin releasing hormone. Anxiety is also a significant trigger of irritable bowel syndrome. Myers and Greenwood-Van Meerveld (2009), mention that exacerbated periods of stress and anxiety have a detrimental effect on the wellbeing of individuals suffering from irritable bowel syndrome. The above studies were able to incorporate similar findings as those of the research by FitzGerald, Kehoe, and Sinha (2009), on the need to manage stress effectively.
Methodology
The study employed both qualitative and quantitative research methods, which ensured that the outcomes would be suitable to use for a better understanding of critical research processes. The testing of the validity and designs were conducted to ascertain the efficacy of the output of the data with regards to the impacts of stress levels on persons suffering from irritable bowel syndrome. Subsequently, the data collection plan employed both the analyses of secondary data and interviews, all of which were instrumental in the formulation of the conclusions regarding the study.
Evidence dissemination
Peer-reviewed journal title Criteria, what has to be submitted Rationale for journal selection, who is on the peer-review committee Stipulations for submission to the journal Journal audience
The role of stress on physiological responses and clinical symptoms in irritable bowel syndrome The nature of the content and ability to meet the stipulated standards of the topical requirements The journal does not specify. However, the publisher analyses qualifications that allow the article to be published as an article Demonstrate the efficacy of the findings regarding the pathophysiological condition Nurses, scholars Medics and students
Role of anxiety in the pathophysiology of irritable bowel syndrome: importance of the amygdala The nature of the content and ability to meet the stipulated standards of the topical requirements The journal does not specify. However, the publisher analyses qualifications that allow the article to be published as an article Demonstrate the efficacy of the findings regarding the pathophysiological condition Nurses, scholars Medics students and society
Effect of prolonged stress on the adrenal hormones of individuals with irritable bowel syndrome. The nature of the content and ability to meet the stipulated standards of the topical requirements The journal does not specify. However, the publisher analyses qualifications that allow the article to be published as an article Demonstrate the efficacy of the findings regarding the pathophysiological condition Nurses, scholars Medics students and society

References
Chang, L., Sundaresh, S., Elliott, J., Anton, P. A., Baldi, P., Licudine, A., … & Ameen, V. Z. (2009). Dysregulation of the hypothalamic‐pituitary‐adrenal (HPA) axis in irritable bowel syndrome. Neurogastroenterology & Motility, 21(2), 149-159.
Chang, L. (2011). The role of stress on physiological responses and clinical symptoms in irritable bowel syndrome. Gastroenterology, 140(3), 761.
FitzGerald, L. Z., Kehoe, P., & Sinha, K. (2009). Hypothalamic—Pituitary—Adrenal Axis Dysregulation in Women With Irritable Bowel Syndrome in Response to Acute Physical Stress. Western journal of nursing research, 31(7), 818-836.
Kano, M., Muratsubaki, T., Oudenhove, L., Morishita, J., Yoshizawa, M., Kohno, K., … & Ly, H. G. (2017). Altered brain and gut responses to corticotropin-releasing hormone (CRH) in patients with irritable bowel syndrome. Scientific reports, 7(1), 12425.
Kennedy, P. J., Cryan, J. F., Quigley, E. M. M., Dinan, T. G., & Clarke, G. (2014). A sustained hypothalamic–pituitary–adrenal axis response to acute psychosocial stress in irritable bowel syndrome. Psychological medicine, 44(14), 3123-3134.
Myers, B., & Greenwood-Van Meerveld, B. (2009). Role of anxiety in the pathophysiology of irritable bowel syndrome: importance of the amygdala. Frontiers in neuroscience, 3.
Sugaya, N., Izawa, S., Saito, K., Shirotsuki, K., Nomura, S., & Shimada, H. (2015). Effect of prolonged stress on the adrenal hormones of individuals with irritable bowel syndrome. BioPsychoSocial medicine, 9(1), 4.