The Case of murdered midwife

The Case of The Murdered Midwife
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The Case of the Murdered Midwife
Part I: The Investigation
The interview would be directed to the medical examiner if the investigator was taking part in the role explained above. Furthermore, I would also interview Melee’s primary doctor, the owner of the bakery shop, her mother as well as her boyfriend. Some of the questions the investigator would inquire are; did the deceased have any medical conditions or any condition that was in her family’s history? Were the samples of the cupcake she bit and of the food being prepared taken? Did the Maleea have any allergies? Were there any other chemicals present in the home? Where was the deceased earlier that day before she got to the house? What was the cause of death of the mother who died during child and did she have any diseases?The investigator would suppose that first either Meleea was in contact with allergens or poisons. Secondly, the deceased might have been exposed to poison or disease when she came into contact with the deceased mother. Lastly, maybe there was a gas leakage from Maleea’s oven.
Part II: The Medical Examiner’s Report
According to the research carried out by Anderson and the information given above, the deceased could have died from gas poisoning. Due to the affixation without any damage or marks done to the mitochondria, the investigator was confident to state the cause of the death. The only process that was interfered with was cellular respiration (Alberts, 2017).

The deceased could have turned on her oven on, and because it was not attended to, the gas might have started to leak and filling her house. The leakage of the gas got rid of all the oxygen in the house causing Maleea’s cells to produce ATP through glycolysis instead of aerobic respiration. This can continue to take place only until the cells begin to die.
The diagnosis of the poisoning caused by carbon monoxide conflict with the pieces of the information provided above. Maleea’s cause of death was suffocation, yet her cells still had a greater concentration of oxygen.
Part III: Analysis of Metabolites
Oxygen as a metabolite in cellular respiration is accepting electrons that have high energy immediately they are detached from glucose. NADH as a metabolite is the electron transporter obtained from niacin, vitamin B3. NAD+ is an oxidized type of NADH and also an electron carrier. NAD+ receives electrons from organic molecules. Under aerobic conditions, the metabolite pyruvate goes into the citric acid cycle which is the final product of glycolysis (Bear et al., 2016). Glucose, alternatively, is used to manufacture energy whereas the Acetyl CoA transports carbon atoms to the TCA cycle from the acetyl group for them to be oxidized to produce energy. ATP metabolite permits cells to store energy which is then transported inside the cell temporarily. It is merely an energy currency for the cell. ADP is generally converted to ATP through cellular respiration. It is made when a particular phosphate group of ATP is lost.
The abnormal metabolites are ADP, NADH, and oxygen which are at extreme levels. ATP and NAD+ are also abnormal due to their low levels (Bear et al., 2016). The normal metabolites are Acetyl CoA, glucose, and pyruvate because of their normal levels.
According to the above answers, the citric acid cycle which is the second phase of cellular respiration was interrupted. This is because the ATP was low thus all the cellular respiration stages were not complete to generate high levels of ATP, NADH, and ADP since they assist in the oxidative stage.
Part IV: Test Results
Sulfane compounds and metals such as cobalt react with cyanide. In cytochrome a3, iron bonds with cyanide. The cyanide keeps the electron from being transported in the cytochrome. Once the transportation of the electron stops, it also prevents the generation of ATP created by oxidative phosphorylation (Toy et al., 2014). The cellular activities get energy from this ATP.
Even though Maleea had high levels of oxygen, she died of asphyxiation since the quantity of cyanide Maleea consumed prolonged her time to die. She still had extreme levels of oxygen even when the second stage of cellular respiration was interfered with. However, the poison she ingested caused her the generation of ATP stop which stopped the intercellular oxygen distribution thus causing her to die from asphyxiation.
References
Alberts, B. (2017). Molecular Biology of the Cell. Second Edition. CRC Press.
Bear, R., Rintoul, D., Synder, B., Smith-Caldas, M., Herren, C., & Horne, E. (2016). Principles of Biology: Overview of Cellular Respiration.
Toy, E. C., Seifert, W.E., Strobel, H. W. & Harms, K. P. (2014) .Case Files Biochemistry 3/E. Third Edition. McGraw Hill Professional.