Dyslipidemia And The Risk Of Atherosclerosis

Dyslipidemia and the risk of atherosclerosis

Lipids as we know are insoluble in blood plasma, so they circulate in the torrent united to proteins, thus forming lipoproteins. These in their superficial part are composed of proteins called amphipatic apoproteins and lipids and its nucleus composed of apolar lipids, such as esterified cholesterol and triglycerides (TG), the richest lipoproteins in lipids are quilomicrones and abundant in proteins areHigh density lipoproteins. Another lipoprotein, very low density or LDL lipoprotein, transports triglycerides synthesized in the liver, that is, of endogenous origin. The blood increase of these two lipoproteins, the quilomicrones and the LDL, raise the circulating concentrations of triglycerides after the meals (postprandial hypertriglyceridemia) or on an empty stomach.

This is where dyslipidemia has genesis, in the metabolism of these lipoproteins, which generate six different dyslipidemia groups, depending on which lipid is altered (i, iia, iib, iii, IV and v) v). A more practical classification distributes dyslipidemias in two already mentioned, primary and secondary groups.

Primary dyslipidemia corresponds to genetic mutations, specifically in the change of the sequence of some nitrogen bases of the DNA and is suspected when it affects children or too premature. The other, the secondary type covers the vast majority of cases in adults, caused frequently by a sedentary lifestyle with a very high intake of saturated fats and cholesterol, as well as various pathologies and drugs already mentioned.

Hyperlipidemia is closely related to atherosclerosis, it is a disease that causes several ailments, such as cardiovascular and cerebrovascular, responsible for high morbidity and mortality worldwide. When we mention arteriosclerosis we generally refer to the hardening of arteries, this is only a generic expression that includes atherosclerosis, this consists of the narrowing of light and loss of flexibility of the walls of the arteries, some years ago they developedNew practices for the study of lesions caused by atherosclerosis, thus considered the autopsy the most complete study method

Aterogenic dyslipidemia is characterized by an increase in lipoproteins rich in triglycerides, but which has been under treated and not taken into account as the main genesis of pathologies still worse. The interest in these has fluctuated a lot over the years due to its important incidence of atherosclerotic cardiovascular diseases to the extreme of discarding them as a cardiovascular risk factor, thus recent epidemiological studies have given life to the incidence of atherogenic dyslipidemia in the disease in the diseaseAteroosclerotic cardiovascular, this associated in the same way that the world is going through systematic changes of its lifestyle more exactly in the increase in consumption of ultra -processed products with high caloric density, sedentary lifestyle that derives in the incidence of obesity and metabolic cardio diseases(Myocardial infarction), factors that are associated with an augmented prevalence of aterogenic dyslipidemia.